Active BioDiscovery Platform

Decode.
Discover.
Advance.

The open computational operating system for genomics, rare disease modeling, and data-driven scientific discovery.

Explore Genome Lab Read NPC1 Study

Discovery Telemetry

0%analysis pipeline readiness

24/7computational research environment

0active research domains

LIVEknowledge synthesis engine

System Modules

Genome IntelligenceVariant analysis · annotation · interpretation

Disease ModelingMechanisms · pathways · therapeutic hypotheses

Computational DiscoverySimulation · screening · literature synthesis

NEAXUS // HOLOGRAPHIC GENOME MAPHUMAN BIOLOGICAL SYSTEM

3D PARTICLE SYNCHRONIZED

Move pointer across canvas to tilt 3D particle helix · click Morph DNA to alter pitch

Genome scancompleteAnnotation engineactivePathway modelstableKnowledge graphsyncedRare disease moduleonlineGenome scancompleteAnnotation engineactivePathway modelstableKnowledge graphsyncedRare disease moduleonlineGenome scancompleteAnnotation engineactivePathway modelstableKnowledge graphsyncedRare disease moduleonline

Research Specimen

Current Focus

NPC1

Niemann-Pick disease type C1

Rare DiseaseLysosomeCholesterolComputational Biology

STRUCTURAL RIBBON MODEL // NPC1

100%

Residue Bounds: 1 – 1278 aa

Transmembrane Passes: 13 Helices

GeneNPC1

Protein ClassMembrane Transport

Primary OrganelleLysosome

Research StateExploratory

Analysis ModeComputational

LIVE SIMULATION HUD CONTROLS

LYSOSOMAL pH ENVIRONMENT5.5

STEROL CONCENTRATION (μM)45 μM

SIMULATION TEMP (K)310 K

TRANSFER RATE0.94 s⁻¹

RMSF FLEXIBILITY2.00 Å

ΔΔG STABILITY1.71 kcal

Discovery Activity

Inspect NPC1 Project

1,200+

Annotated Genomic Variants

500 ns

Molecular Dynamics Trajectories

100%

Open Reproducible Code

6 Domains

Active Computational Pipelines

Institutional Philosophy

Engineering intelligence for biological discovery.

Neaxus Institute of BioDiscovery is built around a simple premise: complex biology becomes understandable when computation, data, and biological reasoning are brought together. We build reproducible computational models and explore foundational questions that lead to new scientific directions.

01 // Genomics

Variant-level evolutionary scoring & structural effect prediction.

02 // Bioinformatics

High-throughput multi-omic pipeline integration & transcriptomics.

03 // Rare Disease

Focusing on NPC1 & lysosomal storage pathways as mechanistic models.

04 // Systems Biology

Dynamic flux balance constraint modeling & organelle dynamics.

Research Matrix