NEAXUSINSTITUTE OF BIODISCOVERY
Discovery Methodology

Translating Biological Questions into Computational Models

Discovery Lab provides a structured, evidence-based pipeline for testing computational biology hypotheses before wet-lab validation.

DOMAIN 01

Disease Mechanisms

Deconstructing molecular cascades driving lysosomal storage disorders and neurodegeneration.

DOMAIN 02

Therapeutic Hypotheses

Virtual chaperone screening and allosteric modulator binding energy evaluation.

DOMAIN 03

Molecular Pathways

Reconstructing sterol trafficking feedback networks and lysosomal pH homeostasis.

DOMAIN 04

Protein Function & Folding

Simulating residue contact dynamics across mutated membrane transport domains.

DOMAIN 05

Literature Mining NLP

Automated extraction of rare gene-phenotype associations from PubMed knowledge graphs.

DOMAIN 06

Systems Biology Flux

Flux balance constraint models for cellular lipid droplet accumulation.

HYPOTHESIS TO REFINEMENT PIPELINE

Interactive BioDiscovery Workflow Engine

Select any stage in our 5-step scientific pipeline to inspect the computational toolset, data inputs, and expected research deliverables.

01 //Question Phase

Active

Identify unresolved biological anomaly or unannotated rare variant phenotype.

COMPUTATIONAL TOOLKIT
  • PubMed API
  • ClinVar Explorer
  • Literature NLP Engine
EXPECTED DELIVERABLE
Formulated research hypothesis & target gene subset